Protein Homeostasis Mixed
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 42 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 14 of 42 genes have a known function matching the annotation |
Why this annotation
Hub genes include ATP5F1B and NDUFA11/NDUFS5 (mitochondrial OXPHOS), NEDD8/SUMO2 (ubiquitin-like protein modification), RAB5C/AP2S1/CLTA (endocytic trafficking), CFL1/BRK1 (actin dynamics), and MRPL33 (mitoribosome). All genes show weak membership and uniform expression, consistent with broadly expressed housekeeping functions. The module mixes OXPHOS, protein homeostasis (SUMOylation, neddylation), and endocytic machinery — a loosely co-regulated housekeeping cluster. In the context of neighboring modules that also contain OXPHOS subunits and translation factors, this module captures peripheral housekeeping genes that co-vary with the core metabolic program.
Genes
ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA, COPS9, COX17, COX8A, EIF2S2, GNB2, HSBP1, LLPH, MRPL14, MRPL33, NDUFA11, NDUFB11, NDUFC2, NDUFS5, NDUFV2, NEDD8, PFN1, PPIA, PPP1CA, RAB5C, ROMO1, RTRAF, SAP18, SNX3, SOD1, SUMO2, TBCA, TFPT, TMEM14C, TMEM230, TMEM258, TRMT112, VDAC2, YWHAB, ZNHIT1
Most correlated modules
- Proteasome UPS · correlation 0.97
- ATP Synthase Complex · correlation 0.96
- Mitochondrial Complex Assembly · correlation 0.96
- Spliceosomal snRNP · correlation 0.96
- Oxidative Phosphorylation · correlation 0.96
- Mitochondrial Biogenesis · correlation 0.96
- Mixed Housekeeping · correlation 0.95
- ER Protein Glycosylation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.