Mitochondrial OXPHOS
Gene co-expression module in Macrophages
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 37 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 37 genes have a known function matching the annotation |
Why this annotation
This is the most coherent OXPHOS module in the batch. Hub genes ATP5MG and ATP5MF are ATP synthase (Complex V) subunits; UQCR11 and UQCR10 are Complex III subunits; NDUFA4 and NDUFA1 are Complex I/IV-associated subunits; COX4I1, COX6B1, and COX7C are Complex IV (cytochrome c oxidase) subunits; SLC25A5 (ANT2) is the mitochondrial ADP/ATP translocator. Together these span Complexes I, III, IV, and V — the full electron transport chain and ATP synthesis machinery. BTF3, EIF3K, ARPC3, NACA, POLR2L, and EEF1B2 are peripheral housekeeping genes co-regulated with the OXPHOS program. Uniform expression across all subsets is consistent with constitutive mitochondrial respiration in macrophages.
Genes
APRT, ARPC3, ATP5F1E, ATP5MF, ATP5MG, BLOC1S1, BTF3, CLTB, COX4I1, COX6B1, COX7C, ECHS1, EEF1B2, EIF3K, HINT1, LSM10, NACA, NDUFA1, NDUFA4, NDUFB8, OAZ1, OST4, PARK7, PFDN5, POLR2L, RACK1, SERF2, SLC25A5, SLC25A6, SMDT1, SRP14, TAF10, TMA7, UFC1, UQCR10, UQCR11, UQCRB
Most correlated modules
- Mitochondrial OXPHOS · correlation 0.96
- Mitochondrial Complex Assembly · correlation 0.93
- Oxidative Phosphorylation · correlation 0.92
- Protein Homeostasis Mixed · correlation 0.91
- Proteasome UPS · correlation 0.89
- Mitochondrial Biogenesis · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.