Oxidative Phosphorylation
Gene co-expression module in Macrophages
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes are predominantly mitochondrial respiratory chain subunits (COX5B, UQCRQ=Complex III, NDUFB7/NDUFB2=Complex I, COX6C=Complex IV) and ATP synthase subunits (ATP5PO, ATP5F1C, ATP5MC3, ATP5PD), plus MICOS13/MICOS10 (mitochondrial cristae organizing system) and MRPL40 (mitoribosome). LAMTOR2, TBCB, and TRAPPC1 are peripheral outliers. The module represents oxidative phosphorylation machinery with uniform expression across macrophage subsets, consistent with housekeeping mitochondrial function.
Genes
ATP5F1C, ATP5MC3, ATP5PD, ATP5PO, COX5B, COX6C, LAMTOR2, MICOS10, MICOS13, MRPL40, NDUFB2, NDUFB7, TBCB, TRAPPC1, UQCRH, UQCRQ
Most correlated modules
- Protein Homeostasis Mixed · correlation 0.96
- ATP Synthase Complex · correlation 0.95
- Mitochondrial Biogenesis · correlation 0.95
- Mitochondrial Complex Assembly · correlation 0.94
- Complex I / NADH Dehydrogenase · correlation 0.94
- Spliceosomal snRNP · correlation 0.94
- ER Protein Glycosylation · correlation 0.93
- Mitochondrial OXPHOS · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.