Proteasome UPS
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 40 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 40 genes have a known function matching the annotation |
Why this annotation
Hub genes include PSMC5, PSMB6, PSMA7, PSMB1 (proteasome 19S/20S subunits), COX6A1 (cytochrome c oxidase/Complex IV), MRPL41 (mitochondrial ribosome), MYL12B/MYL6 (myosin regulatory light chains), SEC61B (ER translocon beta subunit), COPE (COPI vesicle coat), SRSF9 (SR splicing factor), SEM1 (proteasome lid/26S), ELOB (elongin B/ubiquitin ligase). Proteasome subunits again dominate (4 subunits), placing this module as a neighbor to M78 and M97 in the UPS network. The additional cytoskeletal (MYL12B/MYL6), ER (SEC61B), and mitochondrial (COX6A1, MRPL41) genes reflect the mixed housekeeping nature. The proteasome signal is the strongest identifiable program.
Genes
ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1, COPE, COX6A1, DYNLL1, EDF1, EIF3I, ELOB, ETFB, GET3, LAMTOR5, MRPL41, MYL12A, MYL12B, MYL6, NDUFA6, NUTF2, PSMA7, PSMB1, PSMB6, PSMC3, PSMC5, PSMD4, RNF181, RNH1, SEC61B, SEC61G, SELENOH, SEM1, SF3B5, SRSF9, UBL5, UQCRFS1, ZNF706
Most correlated modules
- Protein Homeostasis Mixed · correlation 0.97
- Proteasome UPS · correlation 0.96
- Mixed Housekeeping · correlation 0.96
- Mitochondrial Housekeeping · correlation 0.96
- ATP Synthase Complex · correlation 0.95
- Glycolytic Redox Metabolism · correlation 0.95
- Mitochondrial Biogenesis · correlation 0.94
- ERAD Proteasome · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.