Spliceosomal snRNP
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 39 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 39 genes have a known function matching the annotation |
Why this annotation
The module is strongly enriched in prolif_mac (2-3x). Hub genes include RAN (nuclear GTPase essential for mitosis and nuclear transport), multiple core spliceosomal Sm proteins (SNRPD1, SNRPD3, SNRPE, SNRPF, SNRPG), LSM3 (pre-mRNA splicing), ERH (splicing enhancer), and CCT8 (chaperonin involved in cell cycle). MRPL13/MRPL51/MRPS16 are mitoribosome genes co-expressed in proliferating cells. GLRX5 (iron-sulfur cluster for mitoribosome), PSMG2 (proteasome assembly), FKBP3 (chromatin regulation). The dominant program is spliceosomal RNA processing co-activated with proliferation.
Genes
ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, GLRX5, IER3IP1, LSM3, LZIC, MRPL13, MRPL27, MRPL51, MRPS16, NDUFA9, NDUFS6, NUDCD2, PIN1, PSMA2, PSMA4, PSMB2, PSMC2, PSMG2, RAN, SNRPD1, SNRPD3, SNRPE, SNRPF, SNRPG, SRP9, TIMM10, TMEM14B, TMEM160, TPRKB, UBE2V2, UCHL3, VDAC3, VPS29
Most correlated modules
- ATP Synthase Complex · correlation 0.97
- Mitochondrial Biogenesis · correlation 0.96
- Protein Homeostasis Mixed · correlation 0.96
- Glycolytic Metabolism · correlation 0.95
- ER Protein Glycosylation · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
- Mitotic Spindle Assembly · correlation 0.93
- Mitochondrial Housekeeping · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.