SSB — Small RNA binding exonuclease protection factor La
SSB belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SSB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | RNA Binding/Splicing RNA processing & translation | AIMP1, ATP11B, C1orf43, CCT2, DEDD2, DGKD, ENSA, ENY2 +18 more | |
| Hematopoietic progenitor cells | Chaperonin TRiC Complex Housekeeping | ARL2, CCDC85B, CCT2, CCT3, CCT5, CCT6A, GADD45GIP1, NDUFS5 +4 more | |
| Innate lymphoid cells | Pre-mRNA Splicing RNA processing & translation | AAK1, CDC42SE2, CIB1, DDX46, HNRNPM, KRT10, KTN1, LARP7 +3 more | View in SCUBA |
| Macrophages | Immunoproteasome Induction Inflammatory | CBR1, DAPP1, DYNLT1, EPSTI1, IFI35, LAP3, LGALS9, LYSMD2 +12 more | View in SCUBA |
| Monocytes | Inflammasome Activation Innate immunity | AIM2, APOBEC3G, ARID5B, BATF3, BST2, CASP5, CD47, CNDP2 +4 more | View in SCUBA |
About the gene
| Synonyms | La, La/SSB, LARP3 |
|---|---|
| Chromosome | 2: 169791933-169812064 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES- mediated translation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.