LPL — Lipoprotein lipase

LPL belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LPL's module in each cell type

Cell type	Module	Shares the module with
Macrophages	SPP1 Tissue Remodeling ECM remodeling	BST1, CD52, CHI3L1, CHIT1, CSF1, FBP1, FGR, FN1 +19 more	View in SCUBA
Monocytes	Tissue-Resident Macrophage Tissue adaptation	ALDH1A1, CPED1, DAAM2, EIF4B, FN1, H2AC19, HDAC9, IGHA2 +3 more	View in SCUBA
Pericytes	Fibrotic ECM Remodeling ECM remodeling	BGN, CYGB, LAMC3, LGALS3BP, MMP11, NREP, PCDH18, PLOD2 +2 more	View in SCUBA

About the gene

Synonyms	LIPD
Chromosome	8: 19901717-19967259
Predicted location	Intracellular, Secreted
Essential gene	No
Protein class	Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Molecular function	Heparin-binding, Hydrolase
Biological process	Lipid degradation, Lipid metabolism

Function

Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.