JAK-STAT IFN Signaling
Gene co-expression module in Monocytes
| Category | Antiviral |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes STAT1 and STAT2 are the canonical transcription factors of the JAK-STAT IFN signaling pathway; TNFSF10 (TRAIL) is an IFN-induced apoptosis ligand; PARP9, TRIM22, RNF213, SP110, LAP3, GBP2, DDX60 are all well-established ISGs. The module is strongly upregulated in IBD inflammation and reduced in remission. Core coherence and uniform expression confirm a tight IFN-signaling program. As a neighbor to M43, this module represents the upstream JAK-STAT IFN signaling arm, while M43 represents downstream effector ISGs.
Genes
DDX60, GBP2, LAP3, PARP9, RNF213, SP110, STAT1, STAT2, TNFSF10, TRIM22
Most correlated modules
- IFN-gamma Response · correlation 0.93
- Type I Interferon Response · correlation 0.92
- Immunoproteasome Antigen Processing · correlation 0.87
- Inflammasome Activation · correlation 0.85
- Inflammasome Activation · correlation 0.82
- Type I Interferon · correlation 0.80
- Inflammatory Monocyte Activation · correlation 0.78
- IFN-γ Monocyte Response · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.