Type I Interferon Response
Gene co-expression module in Monocytes
| Category | Antiviral |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
All 10 genes are canonical type I interferon-stimulated genes: IFI44L, IFI44, IFI6 (IFN-inducible proteins), MX1 (antiviral GTPase), OAS2, OAS3 (oligoadenylate synthetases), IRF7 (master IFN transcription factor), PML (IFN-inducible nuclear body), PARP12 (ISG), EPSTI1 (ISG). This is a tightly co-regulated type I IFN response module, distinct from M43 (IFN-γ GBPs) and M92 (JAK-STAT). Core coherence and strong upregulation in IBD inflammation confirm a robust type I IFN antiviral program.
Genes
EPSTI1, IFI44, IFI44L, IFI6, IRF7, MX1, OAS2, OAS3, PARP12, PML
Most correlated modules
- JAK-STAT IFN Signaling · correlation 0.92
- Type I Interferon · correlation 0.92
- IFN-gamma Response · correlation 0.90
- Immunoproteasome Antigen Processing · correlation 0.83
- Inflammasome Activation · correlation 0.79
- Type I Interferon Response · correlation 0.69
- Monocyte Chemokine Secretion · correlation 0.66
- Inflammatory Monocyte Activation · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.