SCUBA

SP110 — SP110 nuclear body protein

SP110 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SP110's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsInterferon Response
Anti-viral
ACAP1, ARHGAP15, BCL2, CD44, CD46, DSE, EML4, FCGR2B +7 moreView in SCUBA
CD4⁺ T cellsInterferon response
Anti-viral
ACBD5, AQP3, BTN2A1, BTN3A2, BTN3A3, CISH, EIF2AK2, ERAP2 +23 moreView in SCUBA
CD8⁺ T cellsInterferon-stimulated Genes
Inflammation
ADAR, GBP1, OAS2, PARP14, PARP9, RNF213, SAMD9, SAMD9L +3 moreView in SCUBA
EndothelialType I Interferon Response
Inflammation
ADAR, DDX60, DTX3L, IFIH1, LAP3, OAS2, ODF3B, PARP9 +3 moreView in SCUBA
Gamma-delta T cellsInterferon Stimulated Genes
Inflammation
AATF, ACSL5, ACTR10, AGL, DDX60, DTX3L, HCLS1, HIF1AN +14 more
Hematopoietic progenitor cellsLymphoid Progenitor TFs
Lymphcyte development
ADAM28, AFF3, ANKRD44, CYFIP2, CYLD, HLA-DMB, MEF2C, PDE7A +4 more
MacrophagesAntiviral ISG Response
Antiviral
ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1 +29 moreView in SCUBA
MonocytesJAK-STAT IFN Signaling
Antiviral
DDX60, GBP2, LAP3, PARP9, RNF213, STAT1, STAT2, TNFSF10 +1 moreView in SCUBA
Mucosal-associated invariant T cellType I Interferon
Inflammation
DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, GBP2, GBP4, HERC5 +18 more
NeutrophilsInnate DNA Sensing ISG
Antiviral
AIM2, GIMAP4, IFI16, IRF2, RNF213, SHISA5, TMEM154, TNFSF10 +1 more

About the gene

SynonymsIFI41, IFI75
Chromosome2: 230165186-230225729
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Molecular functionDNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation

Function

Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.