HSD17B4 — Hydroxysteroid 17-beta dehydrogenase 4
HSD17B4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSD17B4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Interferon Stimulated Genes Inflammation | AATF, ACSL5, ACTR10, AGL, DDX60, DTX3L, HCLS1, HIF1AN +14 more | |
| Macrophages | Oxidative Metabolic Program Mitochondrial & OxPhos | ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more | View in SCUBA |
| Monocytes | Macrophage Innate Activation Innate immunity | DMXL2, FGL2, KCTD12, MPEG1, PTPRC, SAMHD1, TLR4, VPS35 +1 more | View in SCUBA |
About the gene
| Synonyms | DBP, MFE-2, SDR8C1 |
|---|---|
| Chromosome | 5: 119452465-119637199 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Isomerase, Lyase, Oxidoreductase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3- hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.