TMEM109 — Transmembrane protein 109
TMEM109 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM109's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Histone Synthesis S-phase Cell cycle | CDK2, EIF4EBP1, HAT1, HNRNPF, HPRT1, PAQR4, RMI2, SLBP | View in SCUBA |
| Endothelial | Actomyosin Contractility Cytoskeletal | BCAP29, CAPN2, GNB2, INPP5A, ITPRIPL2, LGALS1, LRRC8C, MPRIP +2 more | View in SCUBA |
| Gamma-delta T cells | Effector Cell Migration migration & adhesion | ADAM15, ADAM8, ANXA2, APOBEC3G, CD52, CTSC, DSTN, FUT11 +17 more | |
| Lymphatic endothelial | Metabolic Housekeeping Housekeeping | CAPNS1, CYB5R3, DMAC1, DUT, EID1, ESD, GNAI2, ISCU +5 more | View in SCUBA |
| Macrophages | DNA Replication Metabolism Cell cycle | AGPAT5, CBX1, DCK, FADS1, HACD3, HADH, ICMT, IDH2 +11 more | View in SCUBA |
| Mucosal-associated invariant T cell | Antigen Processing Protein processing & ER | AQP3, ATP5MJ, CAPNS1, CCDC107, CTDNEP1, NCR3, NSA2, PHB2 +8 more | |
| Pericytes | Golgi Vesicular Trafficking Vesicular traficking | APP, CLIC4, CTNNA1, EMP2, GNAS, PAK2, PTTG1IP, SERINC3 +1 more | View in SCUBA |
About the gene
| Synonyms | MGC5508 |
|---|---|
| Chromosome | 11: 60914158-60923443 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Ion channel, Voltage-gated channel |
| Biological process | Ion transport, Transport |
Function
Functions as a voltage-gated monoatomic cation channel permeable to both potassium and calcium (By similarity). Plays a role in the cellular response to DNA damage
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.