SCUBA

SRSF4 — Serine and arginine rich splicing factor 4

SRSF4 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SRSF4's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsMembrane trafficking
Housekeeping
BCL2, CLSTN1, GLB1, GTF2I, HPSE, HSDL2, LENG8, MBIP +19 moreView in SCUBA
CD8⁺ T cellsRNA Processing Mixed
RNA processing & translation
AIP, CALM1, EZR, FUBP1, HNRNPA2B1, HNRNPH3, LCP1, LRRFIP1 +8 moreView in SCUBA
EndothelialEndothelial Quiescence
Endothelial cell development
CCRL2, CDC42EP3, CGAS, CHSY1, CYTH1, HES5, HIPK3, ID1 +7 moreView in SCUBA
Gamma-delta T cellsActin Cytoskeletal Regulation
Cytoskeletal
ACTR2, AP3B1, AP3M1, AZI2, CAPZA1, CEP250, CPSF3, DIDO1 +25 more
Innate lymphoid cellsActin Cytoskeleton Dynamics
Cytoskeleton & motility
ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, CXXC5, FAM136A, FERMT3 +26 moreView in SCUBA
Lymphatic endothelialBasement Membrane ECM
migration & adhesion
BRD4, COL4A1, COL4A2, GOLGA4, ITGAV, PITPNB, PXDN, RAI14 +4 moreView in SCUBA
MacrophagesMicrotubule Organization
Cytoskeletal
CAMSAP2, DESI2, FAF2, HERPUD2, KCMF1, LSM14A, MAPK6, NRDC +14 moreView in SCUBA
PericytesRNA Splicing Processing
Housekeeping
ENY2, PCBP1, PCBP2, PLSCR1, RBM8A, RTN4, SLC3A2, WACView in SCUBA

About the gene

SynonymsSFRS4, SRP75
Chromosome1: 29147743-29181900
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionRepressor, RNA-binding
Biological processmRNA processing, mRNA splicing

Function

Plays a role in alternative splice site selection during pre- mRNA splicing. Represses the splicing of MAPT/Tau exon 10

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.