ORAI2 — ORAI calcium release-activated calcium modulator 2
ORAI2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ORAI2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Signaling Regulation BCR/AP1/NFKb pathway | CBLB, CYTIP, FCRL2, FCRL3, G3BP2, HIVEP1, ITPR2, IVNS1ABP +5 more | View in SCUBA |
| CD4⁺ T cells | TGF-beta response Intercellular communication | CLU, COA1, ELK4, GLUL, GPR18, HDGFL3, RAB27B, RASSF2 +3 more | View in SCUBA |
| Endothelial | Basement Membrane Assembly ECM remodeling | COL15A1, COL4A1, COL4A2, HSPG2, KIFC3, MGAT4A, NDST1, NOL4L +4 more | View in SCUBA |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more | View in SCUBA |
| Macrophages | Lipid-Sensing Transcriptional Lipid metabolism | ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2 +29 more | View in SCUBA |
| Pericytes | Actin Cytoskeletal Remodeling Cytoskeletal | CDC42EP1, DPYSL2, ETS1, FMNL3, HDAC1, LXN, RAI14, SHC1 | View in SCUBA |
About the gene
| Synonyms | C7orf19, CBCIP2, FLJ12474, FLJ14733, H_NH0514P08.8, TMEM142B |
|---|---|
| Chromosome | 7: 102433106-102456825 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Calcium channel, Ion channel |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Pore-forming subunit of inward rectifying Ca(2+) release- activated Ca(2+) (CRAC) channels. Assembles with ORAI1 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.