SCUBA

OSTF1 — Osteoclast stimulating factor 1

OSTF1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

OSTF1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsGamma-delta T cell
Cell contamination
ABHD15, ANKRD28, APOBR, CLIC3, CLIC5, EGLN3, ELOVL6, GLO1 +9 moreView in SCUBA
CD8⁺ T cellsTc17 program
Tc17 program
ABI3, ABRACL, CAPG, CCDC85B, FKBP11, GPR34, IL17A, KLRB1 +4 moreView in SCUBA
EndothelialEndothelial Membrane Transport
Endothelial cell development
AQP1, CDH24, CEBPG, CLIC5, FAP, LSM6, OIT3, RAVER2 +9 moreView in SCUBA
Gamma-delta T cellsActin-based Motility
Cytoskeletal
APBB1IP, CD58, COMMD7, CORO1B, CTSD, EVL, FDFT1, HMOX2 +13 more
Innate lymphoid cellsILC-1 identity
Differentiation
ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 moreView in SCUBA
MacrophagesTranslation Initiation
Housekeeping
AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3D, EIF3E +26 moreView in SCUBA
Mucosal-associated invariant T cellMAIT Tissue Residence
Tissue residence
ANAPC16, ARHGDIB, ATP5IF1, CD3E, CD53, CD99, CTSD, CXCR6 +7 more
Natural Killer cellsNK Cytotoxic Activation
Cytotoxicity
ABI3, ALOX5AP, ARHGDIB, BPGM, CD247, GNPTAB, GZMA, HCLS1 +3 moreView in SCUBA
PericytesInflammatory ECM Remodeling
ECM remodeling
CASP4, CHSY1, FNDC3B, GMFG, ITPRIPL2, LAMB1, MARCKSL1, NECTIN2 +5 moreView in SCUBA

About the gene

SynonymsbA235O14.1, OSF, SH3P2
Chromosome9: 75088514-75147265
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins

Function

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.