SCUBA

GNB2 — G protein subunit beta 2

GNB2 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GNB2's module in each cell type

Cell typeModuleShares the module with
CD8⁺ T cellsVesicle Trafficking
Protein processing & ER
AP2M1, ARF1, CDC37, EWSR1, GHITM, LMAN2, PPP2CA, RAB11B +1 moreView in SCUBA
EndothelialActomyosin Contractility
Cytoskeletal
BCAP29, CAPN2, INPP5A, ITPRIPL2, LGALS1, LRRC8C, MPRIP, NID1 +2 moreView in SCUBA
Gamma-delta T cellsT-bet Effector Differentiation
T cell maturation
ABHD17A, BCL7C, CAPNS1, CHST12, DGKZ, EFHD2, FMNL1, GNAI2 +15 more
Goblet cellsProteostasis Housekeeping
Housekeeping
ADRM1, EIF2S2, MAGOHB, NME1, NUDC, OAZ1, PARK7, PFDN2 +4 moreView in SCUBA
Innate lymphoid cellsInterferon-Stimulated Genes
Inflammation
ALDOA, CRTAP, DAZAP2, DDX39B, EIF4B, GDI1, GRINA, GSTM2 +17 moreView in SCUBA
MacrophagesProtein Homeostasis Mixed
Housekeeping
ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 moreView in SCUBA
Mucosal-associated invariant T cellMitochondrial Housekeeping
Mitochondrial & OxPhos
ARPC3, DUT, GPSM3, LSM2, NAA38, NDUFB10, PLEKHJ1, REX1BD +7 more
Natural Killer cellsHistone Variant Remodeling
DNA regulation & transcription
ARF5, C17orf49, DDOST, H2AX, H2AZ1, H2AZ2, IFT25, MACROH2A1 +2 moreView in SCUBA
NeutrophilsNeutrophil Motility Cytoskeleton
Migration & adhesion
CDKN2D, CNN2, COTL1, CST7, GLIPR1, GMFG, GPSM3, JPT1 +9 more
PericytesG-protein Signaling Scaffold
Housekeeping
BCAP29, FDPS, GNB1, PPIA, RAC1, RAP1A, TRIR, YWHAB +1 moreView in SCUBA

About the gene

Chromosome7: 100673567-100679174
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins, Transporters
Molecular functionTransducer

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.