RAP1A — RAP1A, member of RAS oncogene family
RAP1A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAP1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Rho-Actin Remodeling Cytoskeletal | ANAPC11, ARPC2, ARPC5, ATP6V0B, GNAI2, HNRNPH3, HRAS, KIF5B +9 more | View in SCUBA |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, IL27RA +16 more | View in SCUBA |
| Macrophages | Ubiquitin-Proteasome System Housekeeping | ACTR10, ADSS2, ATXN10, CAND1, CYRIB, DKC1, DPM1, EIF4E +18 more | View in SCUBA |
| Pericytes | G-protein Signaling Scaffold Housekeeping | BCAP29, FDPS, GNB1, GNB2, PPIA, RAC1, TRIR, YWHAB +1 more | View in SCUBA |
| Smooth muscle cells | Post-translational regulators Housekeeping | ANXA11, BAG1, BANF1, CALM3, CAMTA1, ERH, HMGN3, MYO1C +6 more | View in SCUBA |
About the gene
| Synonyms | KREV-1, SMGP21 |
|---|---|
| Chromosome | 1: 111542218-111716691 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Hydrolase |
| Biological process | Neurogenesis |
Function
Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.