NUDT14 — Nudix hydrolase 14
NUDT14 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUDT14's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Oxidative Stress Response Stress | AHR, CD151, CD59, CTTNBP2NL, DSTN, FLOT2, GNB4, GNG5 +11 more | View in SCUBA |
| Gamma-delta T cells | Immature T Cell T cell maturation | A1BG, ACP5, CD38, CD7, ID3, ITM2C, MZB1, NCF1 +7 more | |
| Innate lymphoid cells | Innate Inflammatory Activation Inflammation | ARL6IP5, BST2, CD2, CD63, FTL, HMGB1, ITM2B, MGST3 +7 more | View in SCUBA |
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 more | View in SCUBA |
| Pericytes | Notch Vascular Development Developmental | ADAM15, ECSCR, HYAL2, ICAM2, JAG2, KCNN3, LYL1, MANSC1 +2 more | View in SCUBA |
About the gene
| Synonyms | UGPP |
|---|---|
| Chromosome | 14: 105172938-105181323 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP- glucose, CDP-glucose, GDP-glucose and GDP-mannose
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.