ECSCR — Endothelial cell surface expressed chemotaxis and apoptosis regulator
ECSCR belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ECSCR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitochondrial Oxidative Stress Stress | AGTRAP, AP2M1, ECHS1, EDF1, EIF5A, NEDD8, PARK7, PHPT1 +5 more | View in SCUBA |
| Lymphatic endothelial | ECM Remodeling TGFb migration & adhesion | CCDC80, CCND1, CHRDL1, CRIP1, CTSH, HS3ST1, IARS2, LAMB2 +8 more | View in SCUBA |
| Pericytes | Notch Vascular Development Developmental | ADAM15, HYAL2, ICAM2, JAG2, KCNN3, LYL1, MANSC1, NUDT14 +2 more | View in SCUBA |
About the gene
| Synonyms | ARIA, ECSM2 |
|---|---|
| Chromosome | 5: 139448560-139462743 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Angiogenesis, Apoptosis, Chemotaxis, Differentiation |
Function
Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.