COL5A3 — Collagen type V alpha 3 chain
COL5A3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL5A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Complex Activation TCR/AP1/NFKb pathway | ABHD17A, ACTR3, C1GALT1, CD2, CD3D, CD3E, CD3G, CD81 +14 more | View in SCUBA |
| Glial cells | Glial Neural Scaffolding Cytoskeletal | AKAP6, ARHGAP24, EIF4G2, NFIX, PPP1R12B, SCAF11, SEMA6D, USP53 | View in SCUBA |
| Pericytes | BM Collagen Production ECM production | ANGPT2, COL18A1, COL4A1, COL4A2, ITGA1, MEST, PXDN, SPARC | View in SCUBA |
About the gene
| Chromosome | 19: 9959561-10010504 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted secreted proteins |
Function
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.