PXDN — Peroxidasin
PXDN belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PXDN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ECM Fibrotic Remodeling ECM remodeling | ADAMTS7, ANGPTL2, CD276, CETP, COL18A1, COLGALT1, DDI2, ERO1A +7 more | View in SCUBA |
| Fibroblasts | Wnt-BMP Fibroblast Developmental | ABCC4, BMP7, EMID1, ETS1, GJA1, GNG2, LEF1, MFGE8 +5 more | View in SCUBA |
| Glial cells | Glial Neuroprotective Response Neroprotection | ANXA4, CYB5A, DPYSL3, DRAP1, FADS2, IGFBP4, MDK, NBDY +4 more | View in SCUBA |
| Lymphatic endothelial | Basement Membrane ECM migration & adhesion | BRD4, COL4A1, COL4A2, GOLGA4, ITGAV, PITPNB, RAI14, RB1CC1 +4 more | View in SCUBA |
| Pericytes | BM Collagen Production ECM production | ANGPT2, COL18A1, COL4A1, COL4A2, COL5A3, ITGA1, MEST, SPARC | View in SCUBA |
About the gene
| Synonyms | D2S448, D2S448E, KIAA0230, MG50, PRG2, PXN |
|---|---|
| Chromosome | 2: 1631887-1744852 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Oxidoreductase, Peroxidase |
| Biological process | Hydrogen peroxide |
Function
Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer. In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling. Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity. In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways. Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1485' and leads to bromine enrichment of the basement membranes. In vitro, can also catalyze the two-electron oxidation of thiocyanate and iodide and these two substrates could effectively compete with bromide and thus inhibit the formation of sulfilimine bonds. Binds laminins. May play a role in the organization of eyeball structure and lens development during eye development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.