PCOLCE — Procollagen C-endopeptidase enhancer
PCOLCE belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCOLCE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Proteolytic Fibroblast State ECM remodeling | ANXA2, CTSK, EMP3, LGALS3, MPZL1, ROBO1, S100A10, S100A16 +3 more | View in SCUBA |
| Pericytes | Fibrillar Collagen Production ECM production | COL1A1, COL1A2, COL3A1, COL5A1, COL6A1, COL6A2, COL6A3, GGT5 +1 more | View in SCUBA |
| Smooth muscle cells | ER Chaperone/UPR Protein processing & ER | CALR, CRISPLD2, FBLIM1, HIF1A, HSP90B1, HSPA5, IL6ST, OSMR +3 more | View in SCUBA |
About the gene
| Synonyms | PCPE, PCPE1 |
|---|---|
| Chromosome | 7: 100602363-100608175 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
Function
Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.