RND1 — Rho family GTPase 1
RND1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RND1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-κB Early Response Inflammation | BCL3, BHLHE40, ICAM1, INSIG1, ITPKC, KLF10, LDLR, MYADM +3 more | View in SCUBA |
| Pericytes | EMT-like Remodeling ECM remodeling | APOLD1, B3GNT5, C2CD4B, CFAP20, FAM43A, INSIG1, LDLR, RALGDS +2 more | View in SCUBA |
About the gene
| Synonyms | ARHS, Rho6, RHOS |
|---|---|
| Chromosome | 12: 48857145-48865870 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.