TNFRSF10D — TNF receptor superfamily member 10d
TNFRSF10D belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFRSF10D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Heat Shock Response Stress | BAG3, DNAJA1, DNAJA4, HSPA8, HSPD1, HSPE1, HSPH1, IER5 +2 more | View in SCUBA |
| Fibroblasts | Proteotoxic Stress Survival Stress | ARL5B, BAG3, DNAJA4, ICAM1, PPIF, PPP1R15B, SLC25A25, TIPARP | View in SCUBA |
| Pericytes | EMT-like Remodeling ECM remodeling | APOLD1, B3GNT5, C2CD4B, CFAP20, FAM43A, INSIG1, LDLR, RALGDS +2 more | View in SCUBA |
About the gene
| Synonyms | CD264, DcR2, TRAILR4, TRUNDD |
|---|---|
| Chromosome | 8: 23135588-23164027 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Apoptosis |
Function
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to, it cannot but according to, it can induce the NF-kappa-B pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.