BMP/TGF-beta response
Gene co-expression module in Smooth muscle cells
| Category | Activation |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
ID1, ID2 with KLF10 (TGF-beta early-response gene), RND3/RhoE, IRS2 and SEC11C constitute a canonical BMP/TGF-beta-responsive immediate transcriptional program in mesenchymal/smooth muscle cells; SLC5A3 (osmotic/serum-responsive) and GLS reflect the accompanying metabolic adaptation. The ID-family link to M15 (ID4) supports a shared BMP/SMAD-driven regulatory neighborhood distinct from the proteostasis modules.
Genes
APBB2, GLS, ID1, ID2, IRS2, KLF10, RND3, SEC11C, SIPA1L2, SLC5A3
Most correlated modules
- Translation initiation/RNA-binding · correlation 0.68
- BAG3-HSPB8 proteostasis · correlation 0.65
- Immediate Early Response · correlation 0.62
- STAT3 transcriptional program · correlation 0.61
- Cytoskeletal trafficking kinases · correlation 0.61
- NF-kB Stress Response · correlation 0.61
- Heat Shock Response · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.