ARL1 — ADP ribosylation factor like GTPase 1
ARL1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ER-Golgi Trafficking Vesicular traficking | CALR, COPE, DNAJC3, EMC7, GDI2, MPG, MYDGF, PDIA6 +6 more | View in SCUBA |
| Macrophages | Glycolytic Metabolism Housekeeping | ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5, CIAO2A +30 more | View in SCUBA |
About the gene
| Synonyms | ARFL1 |
|---|---|
| Chromosome | 12: 101393116-101407772 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.