Glycolytic Metabolism
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 39 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 39 genes have a known function matching the annotation |
Why this annotation
This module combines glycolytic enzymes (PGK1=phosphoglycerate kinase, PGAM1=phosphoglycerate mutase, MDH1=cytoplasmic malate dehydrogenase), mitochondrial components (PRDX3=mitochondrial peroxiredoxin, VDAC1=outer membrane channel, NDUFB6=Complex I, ATP5PB=ATP synthase), ER components (VKORC1, KDELR2, TXNDC12), and signaling molecules (RHOA, CALM1, FKBP1A). CIAO2A (iron-sulfur cluster assembly) and GTF2H5 (TFIIH nucleotide excision repair) are additional members. The module is a mixed housekeeping metabolic module spanning glycolysis and mitochondrial metabolism, consistent with general macrophage energy metabolism.
Genes
ARL1, ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5, CIAO2A, COPZ1, ESD, FKBP1A, FXYD5, GOLGA7, GTF2H5, GTF3A, HIKESHI, KDELR2, MCTS1, MDH1, METTL5, MRPL35, MTX1, NDUFB6, NICOL1, PGAM1, PGK1, PHPT1, PRDX3, RFK, RHOA, SNAPIN, SUMO3, TMX2, TPI1, TXNDC12, VDAC1, VKORC1, VMA21
Most correlated modules
- Oxidative Metabolic Program · correlation 0.96
- Glycogen Metabolism · correlation 0.96
- ATP Synthase Complex · correlation 0.95
- Spliceosomal snRNP · correlation 0.95
- ER Protein Glycosylation · correlation 0.95
- Protein Homeostasis Mixed · correlation 0.94
- ER Protein Processing · correlation 0.93
- Oxidative Phosphorylation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.