IDH2 — Isocitrate dehydrogenase (NADP(+)) 2
IDH2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IDH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 lineage Th17 fate | ADA, ARHGEF3, CD226, CD52, DENND3, EVL, IL17RE, IL23R +13 more | View in SCUBA |
| Endothelial | DNA Replication Cell cycle | CENPX, DNMT1, ICMT, MCM3, MCM4, MCM5, MCM6, NR2C2AP +11 more | View in SCUBA |
| Goblet cells | CCT Chaperonin Complex Protein processing & ER | CCT5, CCT6A, HDGF, HNRNPA3, HNRNPC, PTGES3, SMS, SRP9 +2 more | View in SCUBA |
| Hematopoietic progenitor cells | ER Protein Folding Housekeeping | ASRGL1, CALR, CD63, CHPT1, EMP3, GLUL, HSPA5, MLEC +13 more | |
| Macrophages | DNA Replication Metabolism Cell cycle | AGPAT5, CBX1, DCK, FADS1, HACD3, HADH, ICMT, MTHFD1 +11 more | View in SCUBA |
| Smooth muscle cells | Proliferative Biosynthesis Housekeeping | ARF5, BUB3, CBX5, DCTN3, DUT, HMGN2, KRTCAP2, MIF +7 more | View in SCUBA |
About the gene
| Synonyms | IDH-2 |
|---|---|
| Chromosome | 15: 90083045-90102477 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Glyoxylate bypass, Tricarboxylic acid cycle |
Function
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.