AKT3 — AKT serine/threonine kinase 3
AKT3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKT3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | GIMAP survival Immune regulation | ABLIM1, ANKRD13D, ARL4C, C16orf54, CA5B, COPA, CRBN, DYNLT1 +16 more | View in SCUBA |
| Gamma-delta T cells | Innate Stress Signaling Inflammation | B4GALT4, BCR, BLOC1S4, COL6A2, CREBRF, DGKQ, ELF2, FAM53B +23 more | |
| Mucosal-associated invariant T cell | Calcineurin-NFAT Signaling TCR Signaling | CDC14A, IQGAP2, NCALD, NEK7, PLCB1, PLCL2, PPP2R2B, PPP3CA +3 more | |
| Natural Killer cells | NK Cell Activation activation | AHNAK, ANXA1, C16orf54, C1orf162, CD226, CD300A, ITGAX, PLAC8 +2 more | View in SCUBA |
About the gene
| Synonyms | PKBG, PRKBG, RAC-gamma |
|---|---|
| Chromosome | 1: 243488233-243851079 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down- regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.