HSC Quiescence Program
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stemness |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include MEIS1 (master HSC transcription factor), HLF (hepatic leukemia factor, key HSC quiescence TF), HEMGN (hemogen, erythroid/HSC TF), CD164 (HSC marker/adhesion), INPP4B (PI3K pathway, HSC self-renewal), EGLN3 (hypoxia/HIF regulation), NRIP1 (nuclear receptor), SYTL4 (vesicle trafficking). MEIS1 and HLF are canonical markers of long-term HSC quiescence and stemness. HEMGN and CD164 are established HSC-associated genes. PCDH9, CDH7, ADGRG6 suggest cell-cell adhesion in the niche. EGLN3 is involved in hypoxic HSC maintenance. AVP (arginine vasopressin) is unexpected but has been reported in HSC niches. This module strongly represents the HSC quiescence/self-renewal transcriptional program. The neighborhood context (M47 with CDKN1C/quiescence, M31 with cytoskeletal) is consistent with HSC biology.
Genes
ADGRG6, AVP, CCDC175, CD164, CDH7, CHRM3, EGLN3, HEMGN, HLF, INPP4B, MEIS1, NRIP1, PCDH9, PHLDB2, SLC1A6, SYTL4
Most correlated modules
- Megakaryocyte IFN-primed · correlation 0.64
- HSC Stem Identity · correlation 0.58
- Erythroid Maturation Signaling · correlation 0.56
- Interferon Stimulated · correlation 0.37
- Quiescent HSC State · correlation 0.34
- Cytoskeletal Remodeling · correlation 0.33
- Early Myeloid Progenitor · correlation 0.33
- Cytokine Feedback Signaling · correlation 0.31
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.