NK Homing Circulating
Gene co-expression module in Innate lymphoid cells
| Category | Homing & TEM |
|---|---|
| Genes | 46 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
This large module (46 genes, only top 20 shown) contains several highly informative hub genes. SELL (CD62L, L-selectin) is a canonical lymphocyte homing/trafficking receptor enriched 17.6x in circ_ILC3. KLRD1 (CD94, NK receptor), CTSW (cathepsin W, NK/cytotoxic lymphocyte marker), HCST (DAP10, NK activating receptor signaling), ITGB2 (CD18, integrin), RIPOR2 (lymphocyte polarity/migration), FYB1 (ADAP, T/NK cell adhesion), EMP3 (membrane protein, lymphocyte), APOBEC3G (antiviral), IFITM2 (interferon-induced), HOPX (tissue residency marker), PTPRC (CD45). The strong enrichment in circ_ILC3 (circulating ILC3) and the presence of SELL (homing), ITGB2 (adhesion), RIPOR2 (migration), and FYB1 (adhesion signaling) point to a circulating/homing lymphocyte program. KLRD1 and CTSW suggest NK/ILC identity. HOPX is a tissue residency marker but here expressed in circulating cells, possibly marking transitional cells. The dominant theme is circulating NK/ILC identity with homing and adhesion machinery. This is best described as a circulating NK/ILC homing module.
Genes
ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST, CDKN2D, CMC1, CRIP1, CTSW, EMP3, EVI2B, FXYD7, FYB1, GATA3, GNLY, GRK6, HCST, HOPX, IFITM2, IGFLR1, ITGA4, ITGB2, KLF3, KLRD1, LGALS1, LRRFIP1, MATK, NHLRC3, PLAC8, PLP2, PTPRC, PYCARD, RIPOR2, S100A10, S100A6, SELL, SIGIRR, SUN2, TRABD, TSPO, VIM, XCL1, XCL2
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.