DOC2B — Double C2 domain beta
DOC2B belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DOC2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL33 Alarmin Signaling Inflammation | ARHGAP26, CHN1, IL33, MCUB, PTAFR, SDCBP, SLC8A1, STMN3 +1 more | View in SCUBA |
About the gene
| Synonyms | DOC2BL |
|---|---|
| Chromosome | 17: 142789-181650 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium- dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium- triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.