SLC8A1 — Solute carrier family 8 member A1

SLC8A1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SLC8A1's module in each cell type

Cell type	Module	Shares the module with
Endothelial	IL33 Alarmin Signaling Inflammation	ARHGAP26, CHN1, DOC2B, IL33, MCUB, PTAFR, SDCBP, STMN3 +1 more	View in SCUBA
Enterocytes	PPARA/FXR fatty acid oxidation Lipid metabolism	ALDH18A1, ANO10, CPT1A, DGKD, FAT1, FMO5, NDRG1, NR1H4 +4 more	View in SCUBA
Macrophages	Transcriptional Regulation Housekeeping	ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2 +20 more	View in SCUBA

About the gene

Synonyms	NCX1
Chromosome	2: 40097270-40611053
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Molecular function	Calmodulin-binding
Biological process	Antiport, Calcium transport, Ion transport, Sodium transport, Transport

Function

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.