GALNT3 — Polypeptide N-acetylgalactosaminyltransferase 3
GALNT3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GALNT3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing & Trafficking RNA processing & translation | ARF1, ARL6IP1, ARRDC2, B3GNT2, C17orf49, CCDC12, CWC15, DDX39A +19 more | |
| Goblet cells | Protein trafficking & glycosylation Mucus production & secretion | COPA, COPB1, COPB2, COPG1, EDEM3, FAM114A1, GALNT7, TM9SF2 +1 more | View in SCUBA |
About the gene
| Synonyms | GalNAc-T3, HFTC, HHS |
|---|---|
| Chromosome | 2: 165747588-165794659 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, MUC2, MUC1A and MUC5AC. Probably glycosylates fibronectin in vivo. Glycosylates FGF23.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.