NT5C2 — 5'-nucleotidase, cytosolic II
NT5C2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NT5C2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Basal adhesion remodeling Migration & adhesion | EPB41L2, ETS2, FNDC3B, HERC4, ITGA6, SESTD1, SGMS1, SH3RF1 +2 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Response DNA/chromatin regulation | AP1B1, CCAR1, CHD8, DOCK2, EP400, ERBIN, GOLM2, IPO8 +17 more | |
| Lymphatic endothelial | MAPK-ERK Signaling migration & adhesion | ARIH1, BRAF, CPNE8, DENND4A, ELF2, FBXO11, FNDC3B, GRB10 +6 more | View in SCUBA |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARFGEF1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A +48 more | View in SCUBA |
About the gene
| Synonyms | cN-II, GMP, NT5B, PNT5, SPG45, SPG65 |
|---|---|
| Chromosome | 10: 103087185-103277605 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Hydrolase, Transferase |
| Biological process | Nucleotide metabolism |
Function
Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.