GRPEL1 — GrpE like 1, mitochondrial
GRPEL1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GRPEL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Splicing Processing RNA processing | ANXA2R, APOL3, BTN3A1, CCNL1, CHCHD7, CMPK1, DDX5, EIF4A2 +7 more | View in SCUBA |
| Lymphatic endothelial | NRF2 Oxidative Stress Stress | ATP1B3, F3, GCLM, HMOX1, PLIN2, SLC3A2, TXNRD1 | View in SCUBA |
About the gene
| Synonyms | FLJ25609, GrpE, hMGE |
|---|---|
| Chromosome | 4: 7058671-7068085 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.