TXNRD1 — Thioredoxin reductase 1
TXNRD1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TXNRD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | NRF2 Oxidative Stress Stress | ATP1B3, F3, GCLM, GRPEL1, HMOX1, PLIN2, SLC3A2 | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
About the gene
| Synonyms | GRIM-12, Trxr1, TXNR |
|---|---|
| Chromosome | 12: 104215779-104350307 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Electron transport, Transport |
Function
Reduces disulfideprotein thioredoxin (Trx) to its dithiol- containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2). Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. Enhances the transcriptional activity of the estrogen receptor ESR2 only. Mediates cell death induced by a combination of interferon-beta and retinoic acid.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.