NRF2 Oxidative Stress
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
TXNRD1 (thioredoxin reductase 1), HMOX1 (heme oxygenase 1), and GCLM (glutamate-cysteine ligase modifier) are canonical NRF2 antioxidant response targets. PLIN2 (perilipin 2) marks lipid droplet accumulation, often co-induced with oxidative stress. SLC3A2 is a cystine transporter supporting glutathione synthesis. GRPEL1 is a mitochondrial chaperone. F3 (tissue factor) can be induced by oxidative stress. This module represents a coherent NRF2-driven oxidative stress response.
Genes
ATP1B3, F3, GCLM, GRPEL1, HMOX1, PLIN2, SLC3A2, TXNRD1
Most correlated modules
- NF-κB Autophagy Regulation · correlation 0.84
- Hypoxia HIF Response · correlation 0.79
- NRF2 Oxidative Stress · correlation 0.78
- Oxidative Stress Response · correlation 0.77
- Integrated Stress Response · correlation 0.76
- RNA Protein Homeostasis · correlation 0.75
- Apoptosis Immune Regulation · correlation 0.72
- NF-κB Inflammatory Activation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.