HSPB8 — Heat shock protein family B (small) member 8
HSPB8 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSPB8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D +20 more | View in SCUBA |
| Smooth muscle cells | BAG3-HSPB8 proteostasis Stress | BAG3, C6orf62, CREBRF, DNAJB4, EOGT, GOLGB1, IFRD1, PPP2R5E +5 more | View in SCUBA |
About the gene
| Synonyms | CMT2L, E2IG1, H11, HSP22 |
|---|---|
| Chromosome | 12: 119171555-119224855 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chaperone |
| Biological process | Stress response |
Function
Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.