BAG3-HSPB8 proteostasis
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes form a classic chaperone/proteostasis stress axis: BAG3-HSPB8 co-chaperone complex (chaperone-assisted selective autophagy), DNAJB4 (HSP40 family), CREBRF (stress-responsive regulator of CREB3/mTOR-autophagy), IFRD1 (stress-inducible transcriptional coregulator), YME1L1 (mitochondrial AAA protease, protein quality control) and ZC3HAV1 (stress-granule associated antiviral RNA-binding protein). Uniform, low-level expression with no subset enrichment argues against contamination; this is a cell-intrinsic proteostatic stress program, consistent with its neighbor M124 (HSPD1/HSPE1 chaperonins, DUSP1).
Genes
BAG3, C6orf62, CREBRF, DNAJB4, EOGT, GOLGB1, HSPB8, IFRD1, PPP2R5E, PURA, RAB15, YME1L1, YY1, ZC3HAV1
Most correlated modules
- STAT3 transcriptional program · correlation 0.80
- Translation initiation/RNA-binding · correlation 0.71
- Secondary Response Genes · correlation 0.67
- Actin Cytoskeletal Scaffold · correlation 0.67
- Pericyte Basement Membrane · correlation 0.66
- Cytoskeletal Scaffolding · correlation 0.66
- BMP/TGF-beta response · correlation 0.65
- KLF6/ZNF24 regulators · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.