JAM3 — Junctional adhesion molecule 3
JAM3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
JAM3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Adhesion/Migration migration & adhesion | ADAM28, ADAMTS6, ARHGAP24, ARHGAP5, CHPT1, CLMN, CMTR2, FCMR +11 more | View in SCUBA |
| Endothelial | Glucocorticoid Response Endothelial cell development | APOLD1, DENND3, DPYSL2, KLF11, KLF9, MFSD6, NDRG1, PHLPP1 +8 more | View in SCUBA |
About the gene
| Synonyms | JAM-3, JAM-C, JAMC |
|---|---|
| Chromosome | 11: 134069071-134152001 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Biological process | Angiogenesis, Cell adhesion, Differentiation, Spermatogenesis |
Function
Junctional adhesion protein that mediates heterotypic cell- cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity). Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.