KLF11 — KLF transcription factor 11
KLF11 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLF11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Glucocorticoid Response Endothelial cell development | APOLD1, DENND3, DPYSL2, JAM3, KLF9, MFSD6, NDRG1, PHLPP1 +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | Metabolic Homeostasis Housekeeping | ADIPOR1, BIRC3, COQ10B, CREBRF, EIF1AX, GNAI3, H2AC20, KLHL18 +10 more |
About the gene
| Synonyms | FKLF, MODY7, TIEG2, Tieg3 |
|---|---|
| Chromosome | 2: 10042849-10054836 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Apoptosis, Transcription, Transcription regulation |
Function
Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.