KLF9 — KLF transcription factor 9

KLF9 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KLF9's module in each cell type

Cell type	Module	Shares the module with
Endothelial	Glucocorticoid Response Endothelial cell development	APOLD1, DENND3, DPYSL2, JAM3, KLF11, MFSD6, NDRG1, PHLPP1 +8 more	View in SCUBA
Fibroblasts	Inflammatory TF Response Inflammatory	ADAMTS4, CEBPD, CMIP, FOSL2, MAT2A, NR4A1, NR4A2, NR4A3 +2 more	View in SCUBA
Glial cells	Oxidative Stress Response Stress	CAP1, CD59, CXXC5, EEF2, ENO1, HNRNPF, NDUFA11, NFE2L2 +3 more	View in SCUBA
Innate lymphoid cells	ILC3 identity Differentiation	ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more	View in SCUBA
Monocytes	Glucocorticoid Transcription Inflammatory	HECTD1, JDP2, KLF13, PER1, PIK3R1, TMEM123, ZBTB16	View in SCUBA
Mucosal-associated invariant T cell	MAIT Cell Identity T cell maturation	AFF3, DDX3Y, DKK3, DSE, EPAS1, FKBP5, FYN, GLIPR1 +16 more
Natural Killer cells	Gut-Homing NK Maturation Gut residency	ANXA2, BIN1, DHRS7, HECA, IFI27L2, ITGB7, LGALS1, NDUFB7 +5 more	View in SCUBA
Smooth muscle cells	NR4A-ADAMTS Activation Stress	ADAMTS1, ADAMTS4, ADAMTS9, AVPR1A, DUSP8, HIPK2, MYC, NR4A1 +5 more	View in SCUBA

About the gene

Synonyms	BTEB1
Chromosome	9: 70384604-70414657
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Biological rhythms, Transcription, Transcription regulation

Function

Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.