KNSTRN — Kinetochore localized astrin (SPAG5) binding protein
KNSTRN belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KNSTRN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitotic Kinase Cascade Cell cycle | AURKA, CCNB1, CCNB2, CDC20, CDC25B, DEPDC1, FAM72C, FAM72D +6 more | View in SCUBA |
| Endothelial | Mitotic Spindle Cell cycle | ASPM, CCNB1, CDK1, CENPE, CENPF, CKAP2, KIF20B, LMNB1 +14 more | View in SCUBA |
| Goblet cells | Mitotic Spindle Assembly Cell cycle | ARHGAP11A, AURKA, CDKN3, CENPA, CKAP5, CKS2, FAM83D, KIF14 +5 more | View in SCUBA |
About the gene
| Synonyms | C15orf23, FLJ14502, kinastrin, SKAP, TRAF4AF1 |
|---|---|
| Chromosome | 15: 40382721-40394288 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.