KRT18 — Keratin 18
KRT18 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KRT18's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Stress Response Inflammation | ANKS1A, APH1B, ARL4A, BZW2, C1orf21, CCNG1, CCNG2, DNPH1 +9 more | View in SCUBA |
| Enterocytes | Redox Detoxification Stress | CD9, CDX1, CYBA, GSTK1, GSTP1, PYCARD, SEC61B, SERPINB5 +3 more | View in SCUBA |
About the gene
| Chromosome | 12: 52948871-52952906 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cell cycle, Host-virus interaction |
Function
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.