MAGT1 — Magnesium transporter 1

MAGT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MAGT1's module in each cell type

Cell type	Module	Shares the module with
Endothelial	ER-Golgi Trafficking Protein processing & ER	ATL3, DIAPH2, ECE1, EID1, GOLIM4, KTN1, PGK1, SHISA5 +4 more	View in SCUBA
Macrophages	ER Membrane Homeostasis Housekeeping	ATP6V1A, BNIP2, CANX, CAPZA1, CD164, CMTM6, COPB1, EXOC5 +18 more	View in SCUBA

About the gene

Synonyms	DKFZp564K142, IAP, MRX95, OST3B, SLC58A1
Chromosome	X: 77825747-77899271
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Biological process	Transport

Function

Accessory component of the STT3B-containing form of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N- glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Also has oxidoreductase- independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport in epithelial cells (Probable).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.