PGK1 — Phosphoglycerate kinase 1
PGK1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PGK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ATL3, DIAPH2, ECE1, EID1, GOLIM4, KTN1, MAGT1, SHISA5 +4 more | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more | |
| Innate lymphoid cells | mRNA Translation RNA processing & translation | ABHD14B, ARHGDIA, CD2BP2, EEF2, EIF3L, GYPC, H2AJ, HNRNPA0 +6 more | View in SCUBA |
| Macrophages | Glycolytic Metabolism Housekeeping | ARL1, ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5 +30 more | View in SCUBA |
| Natural Killer cells | NK Cytoskeletal Activation Cytoskeleton & motility | CAPG, CLNK, COTL1, EVL, GPR82, ITM2A, PEBP1, PLEKHO1 +3 more | View in SCUBA |
| Pericytes | Immunoproteasome Induction Inflammatory | CANX, GRN, LY6E, NUCB1, PSAP, PSMB8, PSMB9, SELENOW +3 more | View in SCUBA |
About the gene
| Chromosome | X: 77910739-78129295 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Glycolysis |
Function
Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl- coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis. May play a role in sperm motility.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.