CENPX — Centromere protein X
CENPX belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENPX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | RNA Processing RNA processing | ANP32A, CCDC167, CDK4, CYC1, FDPS, GGCT, LSM3, LSM4 +14 more | View in SCUBA |
| Endothelial | DNA Replication Cell cycle | DNMT1, ICMT, IDH2, MCM3, MCM4, MCM5, MCM6, NR2C2AP +11 more | View in SCUBA |
| Gamma-delta T cells | ATP Synthase Complex Mitochondrial & OxPhos | ATP5F1D, ATP5F1E, ATP5MC2, ATP5MC3, ATP5MF, ATP5MG, ATP5MK, ATP5PD +23 more | |
| Goblet cells | Pyroptosis Stress Response Stress | ADAM15, AURKAIP1, CDC37, COMTD1, DDX39A, EEF1D, GSDMD, INF2 +6 more | View in SCUBA |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, DCTPP1 +34 more | View in SCUBA |
About the gene
| Synonyms | CENP-X, FAAP10, MGC14480, MHF2, STRA13 |
|---|---|
| Chromosome | 17: 82018702-82024107 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Cell cycle, Cell division, DNA damage, DNA repair, Mitosis |
Function
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single- stranded. Does not bind DNA on its own.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.