CENPN — Centromere protein N
CENPN belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENPN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitotic Spindle Cell cycle | ASF1B, DDX39A, DTYMK, GGH, HMGB2, HMGN2, LMNB1, STMN1 +3 more | View in SCUBA |
| Endothelial | Mitotic Cell Cycle Cell cycle | ANP32E, BIRC5, CENPW, CKS1B, DTYMK, GGH, PRR11, PTTG1 +3 more | View in SCUBA |
About the gene
| Synonyms | BM039, C16orf60, FLJ13607, FLJ22660 |
|---|---|
| Chromosome | 16: 81006552-81033114 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.