NCR1 — Natural cytotoxicity triggering receptor 1
NCR1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NCR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NK-like Mature gd-T cytotoxicity | ABHD2, ATG9A, CEP78, HAVCR2, HSH2D, IFIT2, ITGAX, KIR2DL1 +14 more | |
| Natural Killer cells | NK TGF-β Regulation Immune regulation | AOAH, CSK, GIMAP5, PPP1R18, PTPN6, PYCR2, SASH3, TGFBR2 +1 more | View in SCUBA |
About the gene
| Synonyms | CD335, LY94, NK-p46, NKP46 |
|---|---|
| Chromosome | 19: 54906148-54916140 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.